Surface Plasmon Resonance (SPR)
Service Features
SPR enables real-time, label-free measurement of binding between molecules, providing affinity, kinetic, and thermodynamic data for mechanistic studies, antibody characterization, and drug screening.
Service Overview
Surface plasmon resonance (SPR) is a label-free optical detection technology that monitors binding between two or more molecules in real time, providing affinity, association and dissociation kinetics, and thermodynamic data for mechanistic studies, antibody characterization, and drug screening.
Service Advantages
- Label-free: no fluorescent or radioactive labels, preserving native molecular states.
- Real-time monitoring: directly observes association and dissociation.
- High sensitivity: detects very low concentrations (picomolar to femtomolar).
- Non-destructive: samples are generally recoverable.
- High throughput: modern SPR instruments support multi-channel parallel detection.
- Kinetics: directly obtains association and dissociation rate constants.
- Accurate quantification: measures mass changes from binding for absolute quantitative information.
Service Workflow
Sample preparation and chip coupling|Gradient concentration injection|Association and dissociation curve acquisition|Regeneration and replicate validation|Kinetic fitting and report delivery
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